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The Modular Brain

  • irenechiandetti
  • Oct 23, 2025
  • 2 min read

A New Map of Connectivity


The Brain As A Complex Network

Think of the brain as a living network, not unlike the internet or social media: 

  • Small-world properties → local clusters are tightly connected, but distant regions can still “talk” to each other through short pathways.

  • Scale-free structure → a few hubs dominate the network, coordinating communication across many different areas. 

Earlier studies mostly looked at the brain as a whole. This research zoomed in on modularity—the division of the brain into smaller, functional clusters.



The Surprise: The Default Mode Network Split Into Three

One of the most fascinating results involves the default mode network (DMN)—the brain’s “idling mode” when we are at rest.

Traditionally seen as a single functional network, the DMN was revealed to be split into three distinct modules:

  • Medial prefrontal module → linked to self-reflection and emotion regulation.

  • Posterior parietal & parahippocampal module → tied to autobiographical memory and spatial navigation.

  • Precuneus & lateral frontal module → a novel finding, suggesting an unexpected influence of executive areas usually associated with planning and control.



Why It Matters

Mapping brain modularity opens exciting possibilities across neuroscience: 

  • Cognitive neuroscience → comparing resting brain modularity with task-based modularity could reveal how the brain reorganizes for different demands.

  • Clinical neuroscience → disruptions in specific modules could serve as biomarkers for neurological or psychiatric conditions.

  • Methods & analysis → the study calls for more sophisticated algorithms to identify functional communities with higher precision.



Conclusion: A New Lens on Brain Organization

This research marks a step forward in understanding how the human brain is structured. It shows that the brain is not just a web of connections, but a system of distinct modules whose organization can shift depending on cognitive state or pathology.


Exploring brain modularity will help us better understand the neural

foundations of cognition, and mental illness,

opening new pathways for neuroscience and medicine.


Source: Laurienti, P. J., Hugenschmidt, C. E., & Hayasaka, S. Modularity maps reveal community structure in the resting human brain. Wake Forest University School of Medicine.

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